Mesterolone is an oral DHT-derivative used as an anti-estrogen and libido booster. Known as Proviron, it binds to SHBG, freeing testosterone, and adds hardness.
Effects on the Body
• Increases free testosterone levels
• Reduces estrogen effects
• Enhances libido and mood
• Improves muscle hardness and density
• Supports fat loss and vascularity
Recommended Dosage
Men: 25–75 mg/day
Women: Not recommended
Half-Life
Approx. 12 hours
### PROVIMED 25 (mesterolone) Tablets
**HIGHLIGHTS OF PRESCRIBING INFORMATION**
These highlights do not include all the information needed to use PROVIMED 25 safely and effectively. See full prescribing information for PROVIMED 25.
PROVIMED 25 (mesterolone) tablets, for oral use
**INDICATIONS AND USAGE**
PROVIMED 25 is a dihydrotestosterone (DHT) derivative indicated for investigational use in increasing free testosterone, controlling estrogen, and enhancing libido and muscle hardness in performance enhancement settings. Not approved for human therapeutic use in many jurisdictions; consult local regulations (1).
**DOSAGE AND ADMINISTRATION**
– Administer orally.
– Adult males: 25 mg to 75 mg per day.
– Adult females: Not recommended due to androgenic effects (2.1).
– Cycle duration: Typically 4 to 8 weeks.
**DOSAGE FORMS AND STRENGTHS**
Tablets: 25 mg mesterolone (3).
**CONTRAINDICATIONS**
– Known or suspected carcinoma of the prostate or breast in males.
– Pregnancy (4).
– Hypersensitivity to mesterolone or any component of the formulation (4).
**WARNINGS AND PRECAUTIONS**
– Androgenic effects: High risk; not recommended for females (5.1).
– Hepatotoxicity: Monitor liver function tests (5.2).
– Cardiovascular risk: May alter lipid profiles; monitor cholesterol (5.3).
– Suppression of endogenous testosterone: Use post-cycle therapy (5.4).
**ADVERSE REACTIONS**
Common adverse reactions include hair loss, acne, and increased aggression (6).
**DRUG INTERACTIONS**
– Anticoagulants: May enhance effects; monitor prothrombin time (7.1).
– Insulin or oral hypoglycemics: May alter glucose levels; adjust doses (7.2).
**USE IN SPECIFIC POPULATIONS**
– Pregnancy: Contraindicated (8.1).
– Lactation: Not recommended (8.2).
– Pediatric use: Not recommended; risk of premature epiphyseal closure (8.4).
– Geriatric use: Increased risk of prostate issues (8.5).
Revised: 08/2025
**FULL PRESCRIBING INFORMATION**
**1 INDICATIONS AND USAGE**
PROVIMED 25 is indicated for investigational use in adults to increase free testosterone levels, reduce estrogen-related side effects, enhance libido, improve mood and mental focus, boost muscle hardness and vascularity, and support fat loss. It is commonly used during cutting cycles or as an adjunct to other anabolic steroids. This product is not approved for any medical condition and should be used under medical supervision.
**2 DOSAGE AND ADMINISTRATION**
**2.1 Recommended Dosage**
Administer orally, with or without food.
– Males: 25 mg to 75 mg daily, divided into 1-2 doses to maintain stable blood levels.
– Females: Not recommended due to high risk of virilization.
– Cycle duration: Typically 4 to 8 weeks. Discontinue if adverse effects occur.
**2.2 Preparation and Handling**
Store tablets in original packaging to protect from light and moisture. Do not crush or chew tablets.
**3 DOSAGE FORMS AND STRENGTHS**
Tablets containing 25 mg mesterolone, supplied in bottles of 50 tablets.
**4 CONTRAINDICATIONS**
PROVIMED 25 is contraindicated in:
– Patients with known or suspected prostate or breast carcinoma.
– Pregnant women (Category X).
– Patients with hypersensitivity to mesterolone or excipients (e.g., lactose monohydrate).
– Patients with severe hepatic insufficiency.
**5 WARNINGS AND PRECAUTIONS**
**5.1 Androgenic Effects**
High androgenic activity may cause significant side effects, including hair loss and acne in males, and is not recommended for females due to virilization risk. Discontinue immediately if androgenic effects are severe.
**5.2 Hepatotoxicity**
May cause elevated liver enzymes or, rarely, peliosis hepatis. Perform liver function tests before and during therapy; discontinue if jaundice or abnormal tests occur.
**5.3 Cardiovascular Effects**
May alter serum lipid profiles, increasing LDL and decreasing HDL, raising the risk of atherosclerosis. Monitor cholesterol levels periodically during treatment.
**5.4 Endocrine Effects**
May suppress hypothalamic-pituitary-gonadal axis, reducing natural testosterone production. Implement post-cycle therapy to restore hormonal balance.
**6 ADVERSE REACTIONS**
Reported adverse reactions include:
– Dermatologic: Acne, oily skin, male pattern baldness in predisposed individuals.
– Psychiatric: Increased aggression, irritability, mood swings.
– Endocrine: Libido changes, testicular atrophy, reduced fertility.
– Cardiovascular: Hypertension, altered lipid profiles.
– Hepatic: Elevated AST/ALT, jaundice (rare).
**7 DRUG INTERACTIONS**
**7.1 Anticoagulants**
May increase bleeding risk with warfarin or other anticoagulants; monitor INR or prothrombin time closely.
**7.2 Hypoglycemic Agents**
May alter blood glucose levels, potentially requiring adjustment of insulin or oral antidiabetic doses; monitor closely.
**7.3 Corticosteroids**
Concurrent use may increase risk of edema, particularly in patients with cardiac or renal conditions.
**8 USE IN SPECIFIC POPULATIONS**
**8.1 Pregnancy**
Category X: May cause fetal harm, including virilization of a female fetus. Contraindicated in pregnant women.
**8.2 Lactation**
Excretion in breast milk is unknown; breastfeeding is not recommended due to potential risks to the infant.
**8.4 Pediatric Use**
Not recommended; may cause premature epiphyseal closure, leading to stunted growth.
**8.5 Geriatric Use**
Increased risk of prostatic hypertrophy or carcinoma; monitor prostate health closely during use.
**9 DRUG ABUSE AND DEPENDENCE**
Controlled substance in some jurisdictions. Potential for misuse leading to physical or psychological dependence, particularly with prolonged use or high doses.
**10 OVERDOSAGE**
Symptoms of overdose may include severe androgenic effects, such as hair loss, acne, or aggression. No specific antidote exists; treat symptomatically and discontinue use immediately.
**11 DESCRIPTION**
PROVIMED 25 contains mesterolone, a dihydrotestosterone derivative with anti-estrogenic and androgenic properties. Supplied as 25 mg tablets for oral use. Excipients include lactose monohydrate, microcrystalline cellulose, and magnesium stearate. Half-life: Approximately 12 hours.
**12 CLINICAL PHARMACOLOGY**
**12.1 Mechanism of Action**
Mesterolone binds to androgen receptors, increasing free testosterone by reducing sex hormone-binding globulin (SHBG) and exerting anti-estrogenic effects to enhance muscle hardness and libido.
**12.3 Pharmacokinetics**
Rapidly absorbed orally; peak plasma levels in 1-2 hours; half-life approximately 12 hours; metabolized in the liver; excreted primarily in urine.
**13 NONCLINICAL TOXICOLOGY**
Animal studies indicate potential carcinogenicity, including hepatic tumors; no human data available. Use caution due to androgenic effects.
**16 HOW SUPPLIED/STORAGE AND HANDLING**
Tablets, 25 mg, in bottles of 50. Store at 20°-25°C (68°-77°F); protect from light and moisture. Keep out of reach of children.
*Manufactured by: Medi Pharma*
